castanyes blaves

Random ramblings about some random stuff, and things; but more stuff than things -- all in a mesmerizing and kaleidoscopic soapbox-like flow of words.

8/06/2009

 

Caption competition

BBC - Magazine Monitor: Caption Competition
Caption Competition
12. At 12:31pm on 06 Aug 2009, LaurenceLane wrote:

The PGA have been urged to rule on the use of polyurethane suits by spectators, even if rain has been forecast.


12:00 UK time, Thursday, 6 August 2009

cap.595.jpg




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5/26/2009

 

Ubuntu trick -- how to reset evolution email

gconftool-2 --recursive-unset /apps/evolution

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5/21/2009

 

Gene by gene turns genome-by-genome

This is a good example of the kind of paper we are probably going to see more and more often in the future:

Gene discovery using massively parallel pyrosequencing to develop ESTs for the flesh fly Sarcophaga crassipalpis
http://www.ncbi.nlm.nih.gov/pubmed/19454017

Get (a) a certain amount of RNAseq reads for your species "X", (b) build as many full-length cDNAs as possible from the fragments and (c) compare against close species in terms of:
  • New interesting cDNAs that don't have hits against existing public cDNAs -- What do they do?
  • Expression patterns -- Are these different to the patterns in other close species?
  • Protein coding evolution -- run pairwise dNdS against closest genome or tree-based dNdS against anĀ existing phylogeny [1,2] -- Does anything show up in a Gene Ontology enrichment analysis?
Then the data is published and stored in a publicly available database, and can be added to the pool to compare against for the next project. Iterate :-)

It used to be gene-by-gene sequencing and it's now transcriptome by transcriptome sequencing. There are still sequence error and sequence coverage issues: one of my first scientific mentors, Prof. Montserrat Aguade was one of the first to do gene sequencing on the Adh gene in Drosophila when doing her PhD in Harvard. People then extended Adh sequencing and analysis to other Drosophila species, then other clades, then other genes, then some gene families like odorant binding proteins for a bunch of Drosophila species or populations, or gene pathways like the insulin pathway, etc.

But now we have a much broader picture with a rather complete transcriptome. And most of the sequencing issues are going to be corrected across the phylogeny in pretty much the same way as allele imputation is filling the gaps at the population genomics level (e.g. 1000 Genomes Project).

I am very excited about all this!

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5/07/2009

 

FC Barcelona 1991 and 2009 -- find the similarities

http://www.youtube.com/watch?v=6OHYAMG5RTk (jump to 1:00)
http://www.youtube.com/watch?v=1-4NpWO4ObU




The guy who jumps to celebrate with the wet coat was a very young Guardiola as a player, yesterday he jumped to celebrate at the same spot as a coach... now in a suit and with much less hair...

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4/28/2009

 

Peston on makein banks safe

BBC - Peston's Picks: Making banks safe
For what it's worth, there are two reasons why it might make sense to force our biggest and most complex banks to hold more capital than their smaller, simpler peers: if big super-banks have the privilege of knowing that we as taxpayers would always bail them out in a crisis, surely they've got to put in place treble protection against the risk that they'd call on us for such help; also the costs of holding the extra capital might encourage them to slim down and simplify their operations.


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4/08/2009

 

Paul Preston on Breaking up banks

The issue here is how to handle financial globalization: bigger UK banks are good to make them well-positioned internationally, which one could argue is good for the UK financial system but, smaller UK banks are good to the retail consumer as pointed in the blog post. What is best? Ensure that big UK banks can compete internationally in making big deals and acquisitions? Or make sure that smaller UK banks are competing against each other within the UK and providing the best retail value?

Same happened with the wave of water, energy and IT privatizations in the last 10 years in Europe. Every country was playing a double game: trying to promote internal competition and avoid national monopolistic practices but also trying to beef up their national water/energy/IT company so that it could be well-positioned to acquire other European, South American, Asian companies...


BBC - Peston's Picks: Tories to break up banks?
Tories to break up banks?

Robert Peston | 12:40 UK time, Wednesday, 8 April 2009

Royal Bank of Scotland and Lloyds TSB could be dismantled after the next election, if the Tories form the government.

George OsborneHere's why I say that, in the form of excerpts from a speech that's just been delivered by George Osborne, the Shadow chancellor.

"We cannot allow one part of our economy to behave in a way that puts the rest of the economy at risk when it fails. We need to think deeply about whether we can sustain banks that are not only too big to fail, but potentially too big to bail.

By dint of its substantial shareholdings the government has a powerful influence over the future structure of the UK banking industry, whether it likes it or not.

When the time comes to sell off those shareholdings we need to think very carefully before simply selling them to the highest bidder without thinking through the consequences for the wider economy.

We should look at whether Britain in fact needs smaller banks.

For it would be a bitter irony if we came out of this crisis with a banking system that was even more concentrated and even riskier than the one we had before it."

The background to these remarks is that Royal Bank's balance sheet is considerably bigger than the total output of the British economy and it liabilities are considerably great than the entire public-sector debt of the UK.

Hence Osborne's allusion to banks that are "too big to bail". Or to put it another way, in rescuing RBS, the government has mortgaged all our economic futures to the rehabilitation of this giant bank.

As for Lloyds, it became far and away the biggest retail bank in the UK when it was permitted to buy HBOS last autumn.

In fact, it only rescued battered HBOS because the deal offered a once-in-a-generation opportunity to become the unchallenged market leader in British retail banking.

So if the next government were to dismantle Lloyds, depriving it of its enormous share of the current-account, savings and mortgage markets, that would be a reputational disaster for Lloyds' management.

There are two further implications of Osborne's remarks: first, that he would privatise Northern Rock as an independent bank, rather than flogging it to another bank; second, that he would ask the City watchdog, the FSA, and the competition authorities to consider whether other big British banks should be broken up. Even those where taxpayers don't have a big stake.

In the City, where I am tapping out this blog, this is big stuff.

To do my normal thing of ramming home the bleedin' obvious, the opinion polls are currently saying Osborne will be the next chancellor. Which means that his ambitions for what our banks should look like after the spring of next year are at least as significant as the future plans of the current chancellor.


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