castanyes blaves

First seminar of the Systems Biology series at the EBI. This series
starts with a strong focus on the modeling side of Systems Biology,
but with the idea of extending it to other subfields.

Title: Drug combinations, gene combinations and cancer
Speaker: Dr Sven Nelander
Affiliation: Goetebourg University
Date & Time: Tuesday 5th May 2009;  14.00-15.00
Location: C202-3, Shared facilities
Host:  Mikhail Spivakov

There is no rational combination theory for different anticancer drugs
so far. One anticancer drug for one step in the pathway, but no
interrelations described.

Increasing number of genotype to phenotype pairs of data sets: what is
the system in the middle?

TCGA with 200 ovarian tumors, first data released last week. Amazing
data production and integrative bioinformatics, but space for more
modeling.

Example: CoPIA

CNV profiles -- transcriptional network -- final mRNA profiles

Now we have 10 million datapoints that with a fully automated
procedure give a testable hypotheses: 3 of the hub (pleiotropic) genes
are not previously implicated in glioma. GO enrichment analysis makes
sense.

PhD student - Theresia Dahl
Peter Gennemark -- mathematical models
Ulrike Nuber
Chris Sander -- old boss
Linda Karlsson-Lindahl
Debora Marks
Niki Schultz
Bodil Nordlander -- now testing one of the new hub genes