castanyes blaves

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Phylogenetic Inference Using Whole Genomes

Phylogenetic Inference Using Whole Genomes - Annual Review of Genomics and Human Genetics, 9(1):217 - Abstract
Phylogenetic Inference Using Whole Genomes

Bruce Rannala1 and ­Ziheng Yang2­
1Genome Center and Department of Evolution and Ecology, University of California, Davis, California 95616; email:
2Department of Biology, University College London, London WC1E 6BT United Kingdom; Laboratory of Biometrics, Graduate School of Agriculture and Life Sciences, University of Tokyo, Tokyo, Japan; email:

The availability of genome-wide data provides unprecedented opportunities for resolving difficult phylogenetic relationships and for studying population genetic processes of mutation, selection, and recombination on a genomic scale. The use of appropriate statistical models becomes increasingly important when we are faced with very large datasets, which can lead to improved precision but not necessarily improved accuracy if the analytical methods have systematic biases. This review provides a critical examination of methods for analyzing genomic datasets from multiple loci, including concatenation, separate gene-by-gene analyses, and statistical models that accommodate heterogeneity in different aspects of the evolutionary process among data partitions. We discuss factors that may cause the gene tree to differ from the species tree, as well as strategies for estimating species phylogenies in the presence of gene tree conflicts. Genomic datasets provide computational and statistical challenges that are likely to be a focus of research for years to come.

Interesting read. The supertree (separate model) method seems to be a dangerous option in certain cases. The performance can even deteriorate with the inclusion of more genes in the dataset.

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