castanyes blaves

http://www.nature.com/uidfinder/10.1038/nature06500


DBC1 is a negative regulator of SIRT1

This are the Ensembl GeneTrees for the SIRT and FAM5A/B/C (DBC1) families, showing the evolutionary history of these genes in the different species present in the Ensembl database:

http://www.ensembl.org/Homo_sapiens/genetreeview?gene=SIRT1
http://www.ensembl.org/Homo_sapiens/genetreeview?gene=DBC1

The SIRT family contains SIRT1, SIRT6 and SIRT7, SIRT4, SIRT5 and SIRT2 and SIRT3. They have one common yeast outgroup, and two other yeast outgroups for some subfamilies, and each subfamily contains outgroups to Ciona or insects and/or C. elegans.

SIRT1 seems to be very basal and conserved with respect to the others, followed by SIRT2 and SIRT3.
SIRT7, on the other side, seems to have evolved faster when compared to the other subfamilies: it contains an extra peptide stretch at the end that none of the other subfamilies has.



For DBC1, we see conservation down to the Euteleostomi (bony vertebrates) level, with the fish Whole-Genome-Duplication very apparent at the top of the GeneTree:



A few gene predictions are partial and so misplaced in the tree, with a very apparent Danio rerio gene (NSDARG00000061051) and some 2x species. In this case, the DBC1 subfamily is the one with the longest internal branch length compared to the other two, and although this could be due to some partial gene predictions influencing the alignment, the alignment for the (non-2x) amniotes looks very good:




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