castanyes blaves

Researchers say they have made the most significant breakthrough for 15 years in the quest to understand the fatal condition Motor Neurone Disease (MND).

http://news.bbc.co.uk/1/hi/health/7266832.stm

http://www.ensembl.org/Homo_sapiens/genetreeview?gene=TARDBP

This is the Ensembl GeneTree for the TARDBP family, showing the evolutionary history of these genes in the different species present in the Ensembl database:

This tree shows the effect of a whole-genome-duplication (WGS) in the fish genomes, resulting in two copies of it in each of the five fish genomes in Ensembl v48. There is a duplication in Drosophila melanogaster, that may have taken place before the speciation of the melanogaster subgroup (D.melanogaster,D.simulans,D.sechellia).

There are 3 extra duplications, one in Dog, one in Monodelphis and a double duplication in Macaca mulatta. Preliminary data seems to indicate that the double duplication is also present in the orang genome, which isn't a very parsimonious occurrence. If we consider
that the duplication took place at the Catarrhini level, it requires three gene loss events in Human and three more in Chimp to explain why we see four copies in the rhesus and orang genomes. All of them seem like real genes, without much doubt about their prediction.




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