Random ramblings about some random stuff, and things; but more stuff than things -- all in a mesmerizing and kaleidoscopic soapbox-like flow of words.
Loss of BRCA2 function impairs DNA repair by homologous recombination and renders cells particularly sensitive to cisplastin and also to PARP (poly (ADP-ribose) polymerase) inhibitors.
This is the Ensembl GeneTree for the PARP family, comprising PARP1, PARP2 and PARP3, showing the evolutionary history of these genes in the different species present in the Ensembl database:http://www.ensembl.org/Homo_sapiens/genetreeview?gene=PARP1
The genetree shows one C.elegans outgroup, Y71F9AL.18
, and places the insect outgroups in the PARP1 subtree, although they should probably be outgroups of all PARP genes. Treefam has the families split into PARP1, PARP2, PARP3 and so on. In the Treefam full trees, only PARP1 contains the 12 Drosophilas outgroup, in agreement with our tree, suggesting that the duplication was after the split with the insects, and PARP1 is still closer to the ancestral gene. The gene predictions for the two Cionas are not perfect, and one copy goes to PARP2 where should probably go to PARP1. There is only a Ciona savigny and no Ciona intestinalis for PARP1. There is one Tetraodon nigroviridis gene that is probably mispredicted: GSTENG00030378001,
and hopefully will get better with the upcoming new gene build.
We can't see a fish-WGD effect on this tree, so the redundant copies where potentially lost after the duplication.
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