Breast cancer 'master gene' breakthrough

http://www.telegraph.co.uk/earth/main.jhtml?xml=/earth/2008/03/12/scicanc112.xml

The breakthrough paves the way for the development of drugs which could
halt the progress of the disease and help save the lives of some of the
44,000 women diagnosed with the illness every year.

This is the Ensembl GeneTree for the SATB1 and SATB2 genes, showing the evolutionary history of this two genes along the different species in Ensembl:

http://www.ensembl.org/Homo_sapiens/genetreeview?gene=SATB1

If shows the fish whole-genome-duplication effect on SATB2, and there is an extra copy as outgroup of SATB2 that is probably pulled there by a bad Tetraodon prediction in SATB1. These may be corrected once the Tetraodon gene build is updated. The insects and C.elegans are outgroups, suggesting a whole-genome-duplication event after the split with the Bilateria.



There is a very small Macaca mulatta prediction. Also a split gene prediction for platypus, involving two
transcripts that are next to each other in the Ultracontig 239, and should probably be merged
into the same gene. The surrounding genes match correctly:



The Treefam tree predicts a duplication in the C.elegans genome (highlighted in blue), compared to C.briggsae and C.remanei:









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